The Sickle Cell Center at Children's Hospital of Michigan is the largest and most comprehensive in the state. The center provides multidisciplinary care for sickle cell patients as well as a public education program to help identify carriers of the sickle cell gene and infants who have the disease at birth.

Additionally the division sees a wide variety of disorders including Idiopathic Thrombocytopenic Purpura (ITP), Autoimmune Hemolytic Anemia, Evan's Syndrome, Idiopathic Aplastic Anemia and Red Cell Membrane disorders.